Analysis and prediction of protective continuous B-cell epitopes on pathogen proteins

Immunome Research

Table 3 The table lists numbers of protective epitopes exhibiting negative or positive feature association when considering all six possible combinations of antigenicity, modification percentage, variability and evolutionary constraint index (ECI)

	antigenicity	modification	variability	ECI
antigenicity	0/110	33/14	31/26	26/23
modification	-	0/110	22/27	19/21
variability	-	-	0/110	15/31
ec	-	-	-	0/110

Note that like for the prediction of protectivity the used modification and variability scores (features) have been used as 1-value, so actual associations have to inverted as well. Each field in the table contains a pair of numbers where the first and second indicate the number of epitopes associated with a Pearson coefficient of < = -0.5 and > = 0.5, respectively. High numbers therefore indicate a strong degree of feature association.